Pharmacology بداية الاختبار بالتوفيق الاسم ثنائي Pharmacokinetics is The study of biological and therapeutic effects of drugs The study of absorption, distribution, metabolism and excretion of drugs The study of mechanisms of drug action The study of methods of new drug development What does “pharmacokinetics” include What does “pharmacokinetics” include? Unwanted effects of drugs Chemical structure of a medicinal agent Distribution of drugs in the organism The main mechanism of most drugs absorption in GI tract is Active transport Filtration Endocytosis and exocytosis Passive diffusion Which statement is true concerning active transport Transport of drugs through a membrane by means of diffusion Transport without energy consumption Engulf of drug by a cell membrane with a new vesicle formation. Transport against concentration gradient Which route of drug administration is most likely affected by the first-pass effect Sublingual Oral Intravenous Intramuscular A highly irritant drug in the form of an aqueous solution can be administered by Subcutaneous injection Intramuscular injection Intramuscular injection Intra-articular injection The volume of distribution is small for lipophilic substances True False Biotransformation of the drug is to render it Less ionized More pharmacologically active More lipid soluble Less lipid soluble Regarding metabolism of drugs, the following statement is wrong Metabolism of drugs may convert prodrug to active metabolites May generate toxic metabolites Phase II metabolism always follow phase I Tobacco smoking causes hepatic microsomal enzyme induction - Concerning factors affecting oral absorption of drugs, the following statement is true Drinking milk interferes with oral absorption of tetracyclines Drinking tea increases oral absorption of iron - Grapefruit juice stimulates p. glycoprotein and increases reverse transport of drugs Metoclopramide increases oral absorption of digoxin The following route is the best method for administration of oily drugs Intravenous Intramuscular Sublingual Intrathecal 1 out of 11 Time's up
